Cpl. Luis Silva, UHP, said the female driver in her 40s was heading eastbound in the westbound lanes of I-80. The woman had reportedly driven her SUV the wrong way into the canyon.
Around 10:45 p.m., Silva said the woman narrowly missed a head-on collision with a semi-truck, instead clipping the trailer of the semi at mile marker 120.
The woman was reportedly taken to the hospital in stable condition, while the driver of the semi-truck was uninjured.
Silva said the woman is suspected to have been impaired during the crash, which is typically a factor in wrong-way crashes. Silva also said the number of wrong-way crashes has declined recently.
The westbound lanes of I-80 at Parleys Canyon were closed through midnight for clean-up and police investigation.
No further information is available at this time.