The crash reportedly occurred just after 12 p.m. on US-20 at milepost 320.
A 19-year-old male from Washington was traveling eastbound on the highway when he lost control of his vehicle, drove through the median into westbound traffic, and struck a Nissan Murano head-on, according to police. The driver of the Nissan, a 22-year-old from Rexburg, reportedly died on the scene.
There was one passenger in the Nissan, a 24-year-old woman from Rigby, who was transported to a local hospital, according to police.
Police said all occupants were wearing seatbelts.
The crash is currently under investigation.