| Game | Date | Opponent | Time (MT) | TV |
| PRE | Wednesday, February 22, 2012 | vs New York Red Bulls | 8:00 PM | |
| PRE | Saturday, February 25, 2012 | vs Los Angeles Galaxy | 6:00 PM | |
| PRE | Wednesday, February 29, 2012 | vs New England Revolution | 6:00 PM | |
| PRE | Saturday, March 03, 2012 | vs NY/LA/NE | TBD | |
| 1 | Saturday, March 10, 2012 | @ Los Angeles Galaxy | 8:30 PM | ABC 4 |
| 2 | Saturday, March 17, 2012 | New York Red Bulls | 8:00 PM | ABC 4 |
| 3 | Saturday, March 24, 2012 | CD Chivas USA | 7:00 PM | CW30 |
| 4 | Saturday, March 31, 2012 | @ Portland Timbers | 8:00 PM | ABC 4 |
| 5 | Wednesday, April 04, 2012 | Montreal Impact | 7:00 PM | CW30 |
| 6 | Saturday, April 07, 2012 | Colorado Rapids | 7:00 PM | CW30 |
| 7 | Saturday, April 14, 2012 | @ Sporting Kansas City | 6:30 PM | CW30 |
| 8 | Saturday, April 21, 2012 | @ San Jose Earthquakes | 8:30 PM | ABC 4 |
| 9 | Wednesday, April 25, 2012 | @ FC Dallas | 6:30 PM | CW30 |
| 10 | Saturday, April 28, 2012 | Toronto FC | 7:00 PM | CW30 |
| 11 | Saturday, May 05, 2012 | New England Revolution | 7:00 PM | CW30 |
| 12 | Wednesday, May 09, 2012 | @ Chicago Fire | 6:30 PM | CW30 |
| 13 | Saturday, May 12, 2012 | @Seattle Sounders FC | 8:00 PM | ABC 4 |
| BYE | Saturday, May 19, 2012 | | | |
| 14 | Saturday, May 26, 2012 | FC Dallas | 7:00 PM | CW30 |
| EXH | Saturday, June 09, 2012 | TBD | 7:00 PM | |
| 15 | Saturday, June 16, 2012 | @ Chivas USA | 8:30 PM | ABC 4 |
| 16 | Wednesday, June 20, 2012 | Los Angeles Galaxy | 7:00 PM | CW30 |
| 17 | Saturday, June 23, 2012 | San Jose Earthquakes | 7:00 PM | CW30 |
| 18 | Saturday, June 30, 2012 | @ Columbus Crew | 6:00 PM | CW30 |
| 19 | Wednesday, July 04, 2012 | Seattle Sounders FC | 8:00 PM | CW30 |
| 20 | Saturday, July 07, 2012 | Portland Timbers | 7:00 PM | CW30 |
| 21 | Saturday, July 14, 2012 | @ San Jose Earthquakes | 8:30 PM | ABC 4 |
| 22 | Saturday, July 21, 2012 | Colorado Rapids | 8:00 PM | CW30 |
| ASG | Wednesday, July 25, 2012 | at&t MLS All-Star Game | TBD | ESPN |
| 23 | Friday, July 27, 2012 | Vancouver Whitecaps | 7:00 PM | CW30 |
| 24 | Saturday, August 04, 2012 | @ Colorado Rapids | 7:00 PM | ABC 4 |
| 25 | Saturday, August 11, 2012 | @ Vancouver Whitecaps | 5:00 PM | ABC 4 |
| 26 | Saturday, August 18, 2012 | FC Dallas | 7:00 PM | ABC 4 |
| 27 | Friday, August 24, 2012 | @ Philadelphia Union | 5:30 PM | NBC Net |
| 28 | Saturday, September 01, 2012 | D.C. United | 7:00 PM | CW30 |
| 29 | Thursday, September 06, 2012 | @ Houston Dynamo | 6:30 PM | CW30 |
| BYE | Saturday, September 15, 2012 | | | |
| 30 | Saturday, September 22, 2012 | Portland Timbers | 6:00 PM | NBC Net |
| 31 | Saturday, September 29, 2012 | @ Chivas USA | 8:30 PM | CW30 |
| 32 | Saturday, October 06, 2012 | @ Los Angeles Galaxy | 7:00 PM | NBC Net |
| 33 | Wednesday, July 18, 2012 | @ Seattle Sounders FC | 9:00 PM | NBC Net |
| BYE | Saturday, October 20, 2012 | | | |
| 34 | Saturday, October 27, 2012 | Vancouver Whitecaps | 7:00 PM | CW30 |
